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Hydroxyzine is a commonly prescribed antihistamine medication for anxiety and itchiness due to allergies.

It can also work as a sedative before surgery or procedure.

Both forms of hydroxyzine are considered to be equivalent to one another.

Close-up of person pouring a pill into their hands from a pill bottle

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If you are taking hydroxyzine, ensure you are aware of potential drug interactions.

This is not a comprehensive list of all drugs that may interact with hydroxyzine.

Drugs That Cause Drowsiness

Many drugs, including hydroxyzine, cause drowsiness.

Healthcare providers will weigh the risks versus the benefits before prescribing both hydroxyzine and another CNS depressant.

If possible, they may avoid the combination.

Hydroxyzine, in rare cases, may also cause a condition called torsades de pointes.

People with prolonged QT intervals should not take hydroxyzine.

Healthcare providers will avoid the combination when possible.

Alcohol

Alcohol causes CNS depression.

Therefore, when taking hydroxyzine, it is also best to avoid drinking alcohol.

If you cannot avoid alcohol, consult your healthcare provider for medical advice before mixing hydroxyzine and alcohol.

Summary

Hydroxyzine is an antihistamine commonly prescribed to treat anxiety or itchiness.

It can also act as a sedative before surgeries or procedures.

It is best to avoid alcohol while taking hydroxyzine.

Consult your healthcare provider for more information about hydroxyzine and drug interactions.

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