Angiotensin-converting enzyme(ACE) inhibitors are oral medications that lower blood pressure.
They may help to lower your risk of stroke.
ACE inhibitors also are used to help control the progression ofdiabetesandkidney disease.
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Researchers continue to investigate ACE inhibitor use in treating liver disease, uterine fibroids, and more.
Off-label drug use is not uncommon.
Talk with your healthcare provider if you have questions about off-label ACE inhibitor use.
This can lead to hypertension.
ACE inhibitors help preventheart failureby reducing blood pressure and fluid retention.
ACE inhibitors can harm a fetus or infant.
Side Effects
ACE inhibitors are generally very well tolerated.
Still, some side effects are possible.
Seek medical attention if this symptom occurs.
If your symptoms pass but recur often, check with your healthcare provider.
Dosage
ACE inhibitor dosing varies depending on other medications you may be taking.
Some ACE inhibitors should be taken with food.
Always check the directions before taking your first dose.
Summary
ACE inhibitors are medications used to treat high blood pressure.
They are also used off-label to treat other conditions such as abnormal heart rhythms or rheumatoid arthritis.
Research continues into potential benefits in other conditions, including cancer and liver disease.
ACE inhibitors can cause side effects like low blood pressure or a dry, hacking cough.
2022 Aug;76(2):469-82.
2021 Feb 1;106(2):e650-9.
2018;71(13):1474-1482. doi:10.1016/j.jacc.2018.01.058
Johns Hopkins Medicine.ACE inhibitors.
American Heart Association.Low blood pressure - when blood pressure is too low.
2024 Aug;11(4):2455-2459. doi:10.1002/ehf2.14706
Ylmaz I.Angiotensin-converting enzyme inhibitors induce cough.Turk Thorac J.
2019;20(1):36-42. doi:10.5152/TurkThoracJ.2018.18014
Bakris GL.Treatment of hypertension in patients with diabetes mellitus.
In: Nathan DM, White WB, eds.UpToDate.
Waltham, Mass: UpToDate; 2021.
Mann JFE.Choice of drug therapy in primary (essential) hypertension.
In: Bakris GL, White WB, eds.UpToDate.
Waltham, Mass: UpToDate; 2021.
