Unlike decongestants taken by mouth, Afrin works directly in the nasal passages for optimal relief.
This can lead to worsening nasal congestion.
Additionally, compared to oral steroids, Flonase is generally associated with fewer and less severe side effects.

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For best results, its recommended to use Flonase routinely as directed by your healthcare provider.
Given that it is anti-inflammatory, it does not cause rebound congestion like Afrin does.
Can You Use Afrin and Flonase Together?
Afrin is indicated for use for congestion only, while Flonase is indicated for congestion and allergy symptoms.
you’ve got the option to use the two medications together to treat year-round allergic rhinitis.
Which Is More Effective?
Determining which works better depends on your specific treatment needs.
Both medications are effective for their respective indications.
Flonase may be the more practical option if you are experiencing chronic congestion due to allergies or sinus inflammation.
It is a better long-term solution, but consistent use is required for the best results.
They are intended for different purposes.
Afrin offers rapid but short-term relief, while Flonase provides long-term benefits by reducing inflammation.
Understanding these differences can help you make an informed decision about which nasal spray best suits your needs.
Afrin may be a better choice for those needing immediate relief from nasal congestion symptoms.
Discuss your options with your healthcare provider to determine the best fit for your unique needs.
American Academy of Allergy, Asthma, and Immunology.Nasal sprays.
Prescribers' Digital Reference.Flonase.
Journal of Allergy and Clinical Immunology.
1999;104(4):s144-149.
doi:10.1016/s0091-6749(99)70310-6