Citrulline(l-citrulline) is a nonessential amino acid that offers several benefits.
That means some supplement products may not contain what the label says.
Verywell / Anastasia Tretiak
What Are the Benefits of Citrulline?
Verywell / Anastasia Tretiak
Citrulline is naturally produced in the body, even if you do not consume it.
Upon ingestion, citrulline breaks down into l-arginine and stimulates the production of the natural compound nitric oxide.
However, very little scientific evidence supports its use for this purpose.
Verywell / Anastasia Tretiak
However, in another meta-analysis, citrulline malate supplementation did not improve muscle strength in healthy, resistance-trained adults.
This systematic review included four studies and 138 assessments.
More well-controlled studies are needed.
No supplement is intended to treat, cure, or prevent disease.
May Reduce Blood Pressure
Citrulline may reduce blood pressure, but more research is needed.
Citrulline is converted to arginine in the body, and arginine increases blood flow.
Always discuss any supplements you take with your healthcare provider.
Few studies have specifically examined the effects of citrulline supplementation on erectile dysfunction.
However, citrulline supplements were taken in combination with the natural phenol transresveratrol.
Larger, long-term studies focused on citrulline alone are needed to further investigate its potential for treating ED.
Does Citrulline Affect Testosterone?
The body converts citrulline into l-arginine then nitric oxide, two compounds that help stimulate testosterone production.
It’s thought that citrulline supplementation could help build testosterone for this reason.
However, more specific studies in humans are needed to prove any link.
How Does Citrulline Work?
Citrulline is a non-essential amino acid, meaning that your body produces it on its own.
Once ingested, the body converts citrulline into arginine in the kidneys.
Afterward, arginine converts into nitric oxide, which dilates blood vessels and improves circulation.
Excess citrulline is eventually broken down by the liver.
It is combined with citrulline to help your body absorb it better.
Citrulline is also added to supplement powders marketed for workouts and weight lifting, which contain many different ingredients.
Some products containcreatineor caffeine and large amounts of specific vitamins and minerals.
Supplement Facts
What Foods Are Rich in Citrulline?
The best source of citrulline is watermelon.
For this reason, it’s best to avoid taking citrulline supplements if you are pregnant or breastfeeding.
Always consult your healthcare provider before starting any new supplements to be safe.
Dosage: How Much Citrulline Should I Take?
There is no standard recommended dose for citrulline.
Studies have used either citrulline or citrulline malate in differing amounts.
Is it Safe to Take Citrulline Everyday?
In studies, 2 to 5 grams of L-citrulline per day has been used for exercise performance enhancement.
Interactions
Supplements may have interactions with prescribed medications.
The following drugs may interact with citrulline supplements:
Other prescription medications could interact with citrulline.
Always discuss your supplement use with a healthcare provider.
Summary
Citrulline is a non-essential amino acid.
There has been a lot of interest in citrulline supplementation for improved athletic performance.
Despite this, the evidence does not support its routine use for athletes.
Currently, there are no standard recommendations for the use of citrulline supplements.
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