Berberine is a supplement used to treat a number of conditions, including polycystic ovary syndrome (PCOS).
Other conditions berberine is sometimes used for include diabetes, diarrhea, andinfertility.
However, more research is needed to prove its effects.
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Improving Fertility
At least two studies have looked at the benefits of berberine for fertility.
Ovulation improved by an average of 25% after four months.
They also felt fewer side effects 12 weeks prior to in vitro fertilization (IVF) treatment.
But it could help them feel more proactive and relaxed about the prospect.
And some research suggests a link between stress and frustrated efforts at conceiving.
Increasing Insulin Sensitivity
Perhaps berberines biggest role is as a potent insulin sensitizer.
People with PCOS typically have insulin resistance.
Insulin allows the body’s cells to use sugar for energy.
Metformin is a medication that is often prescribed to people with PCOS to help manage insulin and glucose levels.
The benefits of berberine have been compared to metformin in those with PCOS.
A nutritionist told the study participants to reduce their intake of carbohydrates and fats.
A calorie range was not provided.
Study participants were also instructed to do moderate to intense exercise for 30 minutes each day.
Berberine lowered insulin and glucose levels about as well as metformin.
They also recorded better HDL (good cholesterol) levels.
Weight loss is more difficult for many reasons, including increased insulin resistance and strong cravings for carbohydrates.
Berberine may offer hope to people with PCOS who struggle with their weight.
Berberine has been shown to reduce the secretion ofleptin, an appetite-stimulating hormone.
Many studies report weight loss, especially in the midsection of the body.
Berberine has been shown to reduce fatty liver.
This is important because it releases energy.
Berberine Side Effects and Interactions
Many people tolerate berberine well.
But it can cause nausea andconstipation,particularly when taken in high doses.
Regular monitoring of liver function tests is recommended for those taking berberine.
This is why it’s important to consult with a healthcare provider before taking berberine.
Berberine is not intended for long-term use.
And nobody should take berberine while they’re pregnant, breastfeeding, or chestfeeding.
How Much Berberine Should You Take?
Berberine can be taken in capsule or liquid form.
Check with your healthcare provider on how much you should take.
Unlike medications, supplements aren’t regulated by the Food and Drug Administration.
Summary
Like all supplements, berberine’s effects can be difficult to trace.
Berberine can cause stomach upset, especially if it’s taken in high doses.
Many product labels recommend taking a 500 milligram tablet with a meal three times a day.
Check with a healthcare provider to verify how much and how often you should take berberine.
2016 Sep 15;14:266. doi:10.1186/s12967-016-0982-x
