Aleve (naproxen), for example, is the strongest available OTC non-steroidal anti-inflammatory pain reliever.

The active ingredient in OTC pain medications and fever reducers varies.

It works by blocking pain signals in the brain.

woman taking an over-the-counter pain and fever reducer

MementoJpeg / Getty Images

It is often the first choice for treatingheadachesand is an effective fever reducer.

It is one of the most commonly overdosed medicines.Acetaminophen can cause liver damage if you take too much.

Do not take acetaminophen with alcohol.

If you’re not careful, you mayaccidentally overdoseon acetaminophen.

Additionally, avoid giving multi-symptom products to children under 6 years of age unless instructed by a healthcare provider.

Seek medical care for any fever in a newborn or young infant.

Talk to your healthcare provider before taking it if you fall into either of those categories.

It reduces swelling and pain, but it is not asteroid.

NSAIDs work by blocking an enzyme calledcyclooxygenase(COX).

This prevents the formation of chemicals in the body known asprostaglandins, which help control inflammation in the body.

Because ibuprofen reduces inflammation, it is better than Tylenol at treating inflammatory pain.

It is often the first choice for treating menstrual pain and sore muscles.

Some people shouldn’t take ibuprofen or should contact their healthcare provider before use.

As an NSAID, ibuprofen may raise the risk ofheart attackorstrokein those who have risk factors.

Ibuprofen can lead to ulcers or bleeding in the digestive tract.

Naproxen can increase the risk of serious conditions such as a heart attack or stroke.

Additionally, talk to your healthcare provider before givingnaproxento a child under 12 years old.

They can help you find the appropriate dosage.

You should also talk to your healthcare provider before taking naproxen if you are 65 or older.

A smaller dosage may be recommended.

Aspirin prevents blood from clotting, so do not take it with blood thinners, also known as anticoagulants.

Several medications can interact with aspirin.

Also, talk with your healthcare provider if you are taking other NSAIDs such as ibuprofen or naproxen sodium.

Your provider may need to change your aspirin dose or alter the doses of your medications.

Children and teens who take aspirin may experience a potentially fatal complication known asReye’s syndrome.

This serious medical condition causes swelling in the brain, liver, and other organs.

If you are pregnant or breastfeeding, speak with your healthcare provider before taking aspirin.

Small doses of aspirin (81 milligrams) are sometimes prescribed for specific conditions during pregnancy.

Two common OTC topical pain relievers arelidocaine patchesanddiclofenaclotion.

Lidocaine:This medication functions as a local anesthetic.

It prevents nerves from sending pain signals, thereby reducing pain.

Higher-strength prescription topicals are available for more severe pain, such aspain triggered by shingles.

Diclofenac:This medication is a topical NSAID.

Be sure to tell your healthcare provider about any medications you are taking before beginning lidocaine or diclofenac topicals.

There is an increased risk of heart attack and stroke with diclofenac.

Summary

There are various kinds of OTC medications that can treat pain and fever.

Not all of them are safe to use if you have certain medical conditions.

They may also be unsafe if you take other medications that can interact with them.

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