Peppermint oil also has antispasmodic properties and is sometimes used.
Anticholinergics
Anticholinergicsare a throw in of antispasmodic designed to block the neurotransmitteracetylcholine.
Anticholinergics stop cell signals that contract muscles in the digestive tract, heart, lungs, and urinary tract.

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Do Anticholinergic Drugs Work?
Some older studies suggest drugs like Buscopan are effective in treating IBS.
These drugs also have fewer problems with side effects.
However, these antispasmodics aren’t currently FDA-approved for any use in the United States.
Medications available in other countries include:
These drugs work by altering the transportation of sodium and calcium.
Direct smooth muscle relaxants very rarely have reports of side effects.
While considered safe for short-term use, peppermint oil is known to cause heartburn in some people.
To avoid this side effect, you might useenteric-coated capsules.
Their coating doesn’t dissolve until it’s farther along in the digestive system, which prevents irritation.
The American College of Gastroenterology recommends peppermint oil for its antispasmodic properties.
Who Should Not Take Antispasmodics
Certain people should avoid antispasmodic drugs.
It’s important to note, however, that these medications may have side effects.
People with certain health conditions may need to use other therapies.
Be sure to discuss IBS medications with your healthcare provider and closely follow their recommendation for treating your condition.
Frequently Asked Questions
No, but they can be helpful.
They can be useful for diarrhea-predominant IBS (IBS-D).
But since constipation is a side effect, these drugs should not be used for people with constipation-predominant IBS.
Other treatments, including dietary changes and alternative therapies, may help.
2020;158(5):1262-1273.e3.
doi:10.1053/j.gastro.2019.12.021
National Institute of Diabetes and Digestive and Kidney Diseases.Symptoms & Causes of Irritable Bowel Syndrome.
International Foundation for Gastrointestinal Disorders.Medications for IBS.
Brenner DM, Lacy BE.Antispasmodics for chronic abdominal pain: Analysis of North American treatment options.Am J Gastroenterol.
2021;116(8):1587-1600. doi:10.14309/ajg.0000000000001266
Pediatric Oncall Child Health Care.Drug index: Mebeverine.
2014 Jul;48(6):505-12. doi:10.1097/MCG.0b013e3182a88357
Osmosis from Elsevier.Antispasmodics (GI spasms): Nursing phrarmacology.
2022 Nov;71(11):2226-2232. doi:10.1136/gutjnl-2021-325821.
Johns Hopkins Medicine.Irritable Bowel Syndrome Treatment.