Alcohol can have negative impacts on the brain, heart, liver, and stomach.

In some people, intolerance or allergy to alcohol can also result in uncomfortable or even dangerous symptoms.

This article discusses allergies to alcohol, symptoms, triggers, tests, and treatment options.

Red wine

Rafa Elias / Getty Images

People with an intolerance to a food or beverage may experience symptoms that are uncomfortable but not life-threatening.

Intolerances do not cause anaphylaxis.

An intolerance to something like food or drink often is experienced in the digestive system.

These include:

An allergy involves the immune system.

Unlike the symptoms of intolerance, an allergic reaction can be serious and even life-threatening.

It can also lead toanaphylaxis, which is an emergency.

In those with a serious wine allergy, a single milliliter of alcohol can trigger a reaction.

This is considered a medical emergency.

The symptoms of anaphylaxis can appear suddenly and will quickly get worse.

Allergens in Wine

There are numerous potential allergens found in wine.

These include proteins, enzymes, dairy products, molds, and ingredients used in the production of wine.

Sulfites, histamines, and tannins are among some of the substances believed to contribute to a wine intolerance.

Sulfites

Sulfites are an ingredient used to make beverages and foods last longer.

They are found in a number of products, including wine and beer.

Histamines

Some people believe that a reaction to histamine causes symptoms after drinking red wine.

Histamine is made during the production process of fermentation.

Tannins

Tannins are a compound derived from the grapes used to produce wine.

Tannins contribute to the flavor and color of wine and can cause intolerance.

Tannins in red wine have also been associated with migraines.

It is likely they will then order allergy tests.

A variety of tests are used to diagnose allergies.

Only a healthcare provider can formally diagnose allergies.

It is possible those with an intolerance to wine may also have an intolerance to other things.

Allergy testing is the only way to formally diagnose allergies.

This could be due to an intolerance to histamine.

Red wine has higher levels of histamine than white wine.

Some alcoholic drinks have higher levels of histamine than others.

Red wine has more histamine than white wine and beer.

Snopek L, Mlcek J, Sochorova L, et al.Contribution of red wine consumption to human health protection.Molecules.

2018;23(7):1684. doi:10.3390/molecules23071684

Health Direct.How alcohol affects your health.

American Academy of Allergy Asthma and Immunology.Food intolerance versus food allergy.

Nemours Kids Health.What’s the difference between a food allergy and a food intolerance?

Australasian Society of Clinical Immunology and Allergy.Alcohol allergy.

Wuthrich B.Allergic and intolerance reactions to wine.Allergol Select.

2018;2(1):80-88. doi:10.5414/ALX01420E

Health Canada.Sulphites - Priority allergens.

Asthma and Allergy Foundation of America.Allergy diagnosis.

In Tannins:Biochemistry, Food Sources and Nutritional Properties(29-58).

NY: Nova Publishers.

2020;10(8):1181. doi:10.3390/biom10081181