Siblings are generally considered the best donors because they get their genes from the same parents.
In some cases, tissues from a matched donor can still trigger a hostile immune response.
Most cases develop within the first few weeks.
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Chronic GvHD
Chronic GvHD is characterized by symptoms that develop more than 100 days after a transplant.
The higher the KPS score, the lower the risk of these specific conditions.
Transplant Selection
The choice of allogeneic transplant plays a central role in GvHD prevention.
While this may increase the risk of acute GvHD, the benefits generally outweigh the risks.
T-Cell Depletion
Other treatment choices play a role in the prevention of GvHD.
These cells are responsible for instigating the immune response.
Removing T-cells makes the graft less likely to act against the recipient’s own cells and tissues.
Conditions treated withex vivoTCD may not.
There are a few other factors that may increase the risk.
A peripheral blood stem cell transplant has a higher risk of GvHD than a bone marrow transplant.
T-cell depletion may be used to reduce the risk.
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Zeiser R, Blazar BR.Acute graft-versus-host disease - biologic process, prevention, and therapy.N Engl J Med.
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