These features can point a healthcare provider in the direction of the underlying cause.
Others may be signs of underlying disease requiring specialist medical care.
Friction
Friction blistersare the most common punch in of blister on the toes.

Elen11 / Getty Images
The blister can range from the size of a pea to the size of a plum.
These blisters can cause pain and inflammation but are usually not a cause of concern.
Moisture
Excessive foot moisture can causemaceration.
This is the softening and breaking down of skin due to the accumulation of sweat or water.
When this happens, fluids can seep beneath breaks in the skin and form a large vesicle.
Tiny blisters can form when sweat clogs the pores in the feet.
Second-Degree Burns
Blisters form in response to asecond-degree burn.
With second-degree burns, blistering is a way to protect underlying tissues from damage.
The time it can take to blister can vary based on your skin key in.
Typically, the toes becomefrostbittenbefore tiny vesicles form, merging into a larger one.
Pain, burning, tingling, and a waxy skin appearance are also common.
Allergies
Different allergic reactions can cause blisters.
In most cases, the release of histamine will cause generalized swelling andhives.
These include:
Treatment
Thetreatment of toe blisterscan vary by the cause.
Among the options:
Should You Pop a Toe Blister?
Blisters are best left alone.
According to the American Academy of Dermatology, you should avoidpopping a blisterbecause it increases the risk ofbacterial infection.
However, if a blister is especially large and painful, you may need to have it drained.
This is especially true if it affects walking.
Speak with your healthcare provider.
If a blister bursts on its own, clean the area with warm water and soap.
The bandage should be changed daily (or more if there is a lot of fluid).
Should You Remove Blistered Skin?
Never remove the skin of a blister after it has been drained or popped.
Other causes include burns, allergies, infections, excessive moisture, and autoimmune skin conditions.
Toe blisters should be treated gently to aid with healing.
Do not peel or pop blisters as this could lead to a bacterial infection.
American Academy of Dermatology Association.How to prevent and treat blisters.
2017;26(4):159-165. doi:10.12968/jowc.2017.26.4.159
Medline Plus.Burns.
Northwestern Univerity.When should I see a doctor for sunburn?
Alberta Health Services (Canada).Frostbite: care instructions.
2019 Aug 26;2:100014. doi:10.1016/j.jtauto.2019.100014
Seattle Children’s Hospital.Insect bite.
National Health Service (UK).Herpetic whitlow (whitlow finger).
American Academy of Family Physicians.Impetigo: diagnosis and treatment.
doi:10.7759/cureus.10839
National Health Service (UNK).Epidermolysis bullosa.
Sullivan T, de Barra E.Diagnosis and management of cellulitis.Clin Med (Lond).
2018;18(2):1603. doi:10.7861/clinmedicine.18-2-160
National Eczema Association.Is it eczema or psoriasis?
National Health Service (UK).Blisters.