If the person inherits two different types, that is referred to as beingheterozygous.
Even with one copy HLA-DQ8, your risk more than doubles.
However, heterozygosity doesn’t always mean less risk.
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In Europe, for example, it is the most associated with celiac disease and juvenile diabetes.
Not that it matters in terms of disease progression.
To date, there is no suggestion that either serotype has any impact on the severity of the disease.
Lazar-molnar E, Snyder M.The Role of Human Leukocyte Antigen in Celiac Disease Diagnostics.Clin Lab Med.
2012;104(5):248-54. doi:10.4321/s1130-01082012000500005
