It primarily affects the lungs but can affect other organ systems, in some cases proving fatal.
A key feature of Churg-Strauss syndrome is a high number of white blood cells called eosinophils (hypereosinophilia).
This article explains the cause of Churg-Strauss syndrome, its symptoms, and how it is diagnosed and treated.
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What Is Churg-Strauss Syndrome?
Usually, the body releases eosinophils during allergic reactions andparasitic infections.
With Churg-Strauss syndrome, large numbers of the cells are released and accumulate in the body’s tissues.
The symptoms of the disorder will correspond to the organ systems where theeosinophilsare most concentrated.
What Are the Stages and Symptoms of Churg-Strauss ?
The first symptoms (which occur during the prodromal phase) are usually respiratory.
Many people with Churg-Strauss syndrome will experience neurological symptoms, includingpolyneuropathy.
How rare is Churg-Strauss syndrome?
Churg-Strauss syndrome is very rare.
Most cases are diagnosed between the ages of 30 and 50.
Causes of Churg-Strauss Syndrome
The exact cause of Churg-Strauss is unknown.
Some findings include:
How Is Churg-Strauss Syndrome Diagnosed?
Sometimes tissuebiopsiesare taken to look for high levels of eosinophils in specific organs.
Churg-Strauss syndrome can be fatal if left untreated.
Diagnosing the condition early and beginning treatment can help reduce inflammation and prevent the progression to more serious symptoms.
Most people will begin treatment with medications that suppress their immune system, calledcorticosteroids.
One of the most commonly prescribed corticosteroid or steroid medications isprednisone.
People with advanced disease may also need to take cytotoxic medications such as cyclophosphamide or methotrexate.
Many people achieve complete remission from their symptoms.
Left untreated, Churg-Strauss can cause potentially fatal complications.
Talk to your healthcare provider if you have concerns about the disorder or experience specific symptoms.
American Academy of Allergy Asthma & Immunology.Churg-Strauss Syndrome.
National Organization for Rare Disorders.Eosinophilic granulomatosis with polyangiitis.
2022 Aug 14;14(8):e28018.
American College of Rheumatology.1990 Criteria for the Classification of Churg-Strauss Syndrome.
About Eosinophilic Granulomatosis with Polyangiitis (EGPA).
