That is one of the reasons for its growing popularity among people with frequentmigraine headaches.
CoQ10 has not been approved by the Food and Drug Administration (FDA) for migraine prevention.
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What Is CoQ10?

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In fact, mitochondria are often referred to as “the powerhouses of cells.”
When these tiny structures don’t function properly, nearly every system in the body can be affected.
Mitochondrial problems are linked to a variety of diseases and conditions.

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Can CoQ10 Prevent Migraines?
Only a few studies have looked at coenzyme Q10 as a migraine prophylactic (preventive measure).
It stated that high-quality, large randomized control trials are needed to fully evaluate the efficacy and safety.
That means some supplement products may not contain what the label says.
Warnings and Interactions
There are few medications known to potentially interact with coenzyme Q10 supplements.
Side effects are minimal, especially compared to drugs.
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National Center for Complementary and Integrative Health.Coenzyme Q10.
Saini R.Coenzyme Q10: the essential nutrient.J Pharm Bioallied Sci.2011 Jul-Sep;3(3):466-7. doi:10.4103/0975-7406.84471