This includes the immediate-release version of Adderall called Adderall IR and the extended-release version calledAdderall XR.
This mostly occurs in the liver.
Where Vyvanse differs is that it is aprodrug, whereas Adderall is anactive drug.
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With an active drug like Adderall, the ingredientsamphetamineanddextroamphetaminedirectly increase levels of dopamine and norepinephrine in the brain.
When the drugs are metabolized, they become inactive and are eliminated.
With a prodrug like Vyvanse, the ingredientlisdexamfetamineis inactive.
Once dopamine and norepinephrine levels are increased, dextroamphetamine is inactivated and eliminated.
Because of this, prodrugs are less likely to cause toxicity or side effects.
This is because only a portion of Adderall you take by mouth is absorbed into the bloodstream.
All three drugs are available as generics.
It is prescribed as follows:
Side Effects
Vyvanse and Adderall have strikingly similar side effects.
These include:
Seek immediate medical care if you have signs or symptoms of any of these condtions.
Who Should Avoid Vyvanse or Adderall?
CNS stimulants are contraindicated for use in certain people.
This makes drug adherence easier, which most studies suggest improves the effectiveness of treatment.
Summary
Vyvanse and Adderall are prescription stimulant medications used to treat ADHD in adults and children.
Centers for Disease Control and Prevention.Treatment of ADHD.
DailyMed.Adderall XR - dextroamphetamine sulfate, dextroamphetamine saccharate, amphetamine sulfate and amphetamine aspartate capsule, extended release.
DailyMed.Vyvanse - lisdexamfetamine dimesylate capsule; Vyvanse - lisdexamfetamine dimesylate tablet, chewable.
DailyMed.Adderall - dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate, and amphetamine sulfate tablet.
American Academy of Child and Adolescent Psychiatry.ADHD and the brain.
2022 Oct 5;35(11):1337-1344. doi: 10.1515/jpem-2022-0344
MedlinePlus.Lisdexamfetamine.
