In rheumatoid arthritis, methotrexate helps decrease the activity of the immune system.
NSAIDs
Nonsteroidal anti-inflammatory drugs(NSAIDs) are used to relieve pain and decrease inflammation.
It may also increase the risk of cancer (notably, skin cancer) over long-term treatment.
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More study, however, is needed.
Cancer Medications
Methotrexate itself is used in cancer care.
Methotrexate use in cancer may lead to adverse health effects, such as toxicity.
Speak to your healthcare provider about any possible immunizations you might and cannot receive.
Moderate Methotrexate Interactions
Taking methotrexate and some medications will pose a moderate risk of drug interactions.
These interactions are not as dangerous as those above, but they do pose health risks.
The antipsychotic medications that increase the risk for adverse effects are those that affect the liver.
One such medication is chlorpromazine.Another medication that can increase the risk for liver toxicity is Cymbalta (duloxetine).
Using methotrexate over a long period of time has also been linked to liver conditions such ascirrhosis.
Typically, taking these drugs along with methotrexate wouldnt require any change in dose or medication.
Immunosuppressants
When used in conjunction with methotrexate, many immunosuppressants should be avoided.
However, some are safe to use.
Food Interactions
Many people dont consider food interactions when taking new medications.
Drinking alcohol while taking this medication has been shown to increase the risk of liver toxicity.
If you do experience any side effects, be sure to contact your healthcare provider.
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