Prolia works differently from Evenity by binding to a different protein called RANK ligand (RANKL).
They are both given as a subcutaneous injection.
Which Costs More?
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The price for Evenity and Prolia can vary depending on several factors, such as your insurance status.
There are nobiosimilarsof Evenity.
Evenity side effect includes an increased risk for stroke, heart attack, and heart-related death.
Talk to your prescribing healthcare provider to help determine which medication is best for you.
While few studies have compared the effectiveness of Evenity vs. Prolia, both medications are effective at treating osteoporosis.
One study compared the active ingredient of Evenity to Prolia in postmenopausal women.
It is also important to note that everyone responds differently to medications.
Consider having a conversation with your healthcare provider to help decide which is the best medication for you.
Can You Switch Between Evenity and Prolia?
However, switching from one medication to another medication will require careful monitoring and guidance from your healthcare provider.
Summary
Both Evenity and Prolia are effective medications to treat osteoporosis but have key differences.
Evenity works by blocking a protein called sclerostin and ultimately increases bone formation and decreases bone breakdown.
Prolia binds to a different protein called RANKL and prevents it from activating its receptor, RANK.
Prolia decreases the amount of bone that is broken down and increases bone density.
The dose of Evenity is two prefilled syringes given subcutaneously once a month for 12 months.
The dose of Prolia is one prefilled syringe given subcutaneously every six months.
The most common side effects for Evenity are headaches and joint pain.
The most common side effects of Prolia are back pain and musculoskeletal pain.
Both medications can cause serious side effects, like hypocalcemia and severe allergic reactions.
Evenity can also increase your risk of experiencing a stroke, heart attack, and heart-related death.
National Institutes of Health.
DailyMed.Label: Evenity-romosozumab-aqqg injection, solution.
Yu S, et al.Drug discovery of sclerostin inhibitors.Acta Pharm Sin B.
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National Institutes of Health.
DailyMed.Label: Prolia-denosumab injection.
Food and Drug Administration.Jubbonti label.
Khosla S, Hofbauer LC.Osteoporosis treatment: recent developments and ongoing challenges.
2017;5(11):898-907. doi: 10.1016/S2213-8587(17)30188-2.
