Uncontrolled high blood pressure, or resistant hypertension, is hard to manage.
A new way to treat hypertension has been a long time coming.
Blocking receptors to endothelin produces vasodilatation.
Illustration by Julie Bang for Verywell Health
Researchers evaluated Tryvio in the PRECISION trial, which was conducted from 2018 to 2022.
Is Tryvio Safe?
Some people might experience liver problems, fluid retention, decreased sperm count, or anemia while taking Tryvio.
The reason why Im cautious is we dont have long-term data from this medication, Cingolani said.
We dont have five years or a decade.
We do have long-term experience from other similar medications, and they seem to be safe, Cingolani said.
The FDA took a good two years to approve it.
It went through all the studies, and I think the evaluation was quite rigorous, he said.
Im pretty confident that this is going to be a good medication.
This drug is only approved for use with other antihypertensive medications.
It is not a panacea at all, and thats what we expect.
Watson said that taking lower doses can help reduce side effects.
Most people with hard-to-treat hypertension take four different classes of medication.
Watson, like Cingolani, said she will keep Tryvio in her toolbox to treat resistant hypertension.
However, its not the first medication she will reach for.
Its not a game changer, but its nice to have options, Watson said.
What This Means For You
Tryvio (aprocitentan) is a new drug for treating resistant hypertension.
The medication could help people manage uncontrolled high blood pressure when used with other treatments.
Experts doubt it will immediately become a first line of defense.
American Heart Association.Resistant hypertension - high blood pressure that’s hard to treat.
Johns Hopkins Medicine.Resistant hypertension.
National Cancer Institute.Endothelin receptor antagonist.
MedlinePlus.High blood pressure medications.
