Depression research is ever-evolving.
The results of this study were published inCell Metabolismlast month.
What Is Proline?
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Proline-rich Foods
Proline is primarily found in many animal-sourced foods.
Most meats, fish, and dairy foods contain proline as well.
Plus, it tends to focus on major depression instead of all levels of severity.
From there, they analyzed whether there was a relationship between their depression diagnosis and their gut microbiome composition.
Once again, proline was the dietary factor with the strongest impact on depression.
Fernandez-Real told Verywell that the results were quite surprising.
The mice who received the bacteria highest in proline showed more depressive symptoms.
The final step of the study involved fruit flies.
Like the mice, the flies who received proline-rich bacteria exhibited signs of depression.
Fernandez-Real noted that the research team did observe that some subjects with a high intake of proline werenotdepressed.
Should You Avoid Proline To Reduce Your Depression Risk?
There are methods to treat this condition, and sharing concerns is the first step to management.
But lifestyle modifications can help offset that risk.
2021;278:131-135. doi:10.1016/j.jad.2020.09.065.
Mayneris-Perxachs J, Castells-Nobau A, Arnoriaga-Rodriguez M, et al.Microbiota alterations in proline metabolism impact depression.Cell Metabolism.
2022;34(5):681-701.e10.
doi:10.1016/j.cmet.2022.04.001
Lopez MJ, Mohiuddin SS.Biochemistry, essential amino acids.
In:StatPearls[Internet].
StatPearls Publishing: 2022.
MedlinePlus [Internet].Amino acids.
National Library of Medicine: 2022.
Karna E, Szoka L, Huynh TYL, Palka JA.Proline-dependent regulation of collagen metabolism.Cell Mol Life Sci.
2020 May;77(10):1911-1918. doi:10.1007/s00018-019-03363-3
National Institute on Aging.Depression and older adults.
