People who have a uterus areoften recommendedto take combination hormone therapyestrogen and progestogento protect against uterine cancer.

But this therapy doesnt seem to reduce dementia risk.

Mosconi said that her team sought to clear up confusion and locate trends in the study results.

Alzheimer’s treatment research

Photo Illustration by Amelia Manley for Verywell Health; Getty Images

But when it was published, Maki ran a calculation called a number needed to treat.

She found that 2,004 women would need to take estrogen to prevent a single case of death from dementia.

What are the risks you are accumulating among those 2,004 women?

If they had, the conclusions in the meta-analysis may have been tempered.

Im very, very cautious.

I dont think the data shows any clear sign.

Observational studies can also present problems, she added.

Either way, those observational studies can lead to skewed results.

Besides, Mosconi said, denying one group a potentially beneficial treatment for that long poses ethical challenges.

For which women is menopause a risk factor?

According to the CDC, certain conditions including obesity, diabetes, and depression are linked to Alzheimers risk.

Managing those conditions in mid-life can slow long-term cognitive decline.

They need to engage in aerobic exercise.

What This Means For You

Each persons experience in menopause is different.

it’s possible for you to find a list of menopause-aware providers on theNorth American Menopause Society website.

2019;364:l665.

2022;99(17):e1835-e1842.

2021;374:n2182.

2023;100(2):e133-e141.

doi:10.1212/WNL.0000000000201401

Centers for Disease Control and Prevention.Dementia risk reduction.