It is primarily involved in the allergic response but also fights infections from parasites.
Blood tests for IgE can be used to diagnose allergies.
In the case ofallergens, the substance typically is not harmful to most people.
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However, people who generate IgE to allergens can be negatively affected once they develop a sensitization.
This process takes place in lymphoid tissues such as the tonsils, adenoids, and bone marrow.
IgE then diffuses through the tissues and into the bloodstream.
Local synthesis (production) of IgE can occur in the bronchial and nasal mucosa.
A defining characteristic of IgE is the heavy chains, called epsilon.
IgE has four constant regions, which makes the molecule heavier.
IgE Receptors and Their Function
IgE binds to two types of receptorshigh-affinity receptors and low-affinity receptors.
These are immune system blood cells with granules containing chemicals involved in allergic reactions.
IgE binding triggers different effects in cells.
This is called negative feedback and is how the immune system regulates itself.
The total amount of IgE in your blood can be measured.
Another jot down of test, called a specific IgE test, can also be used.
A specific IgE test measures how much IgE your body makes to a specific allergen.
Othertypes of allergy testsmay be used, such as skin tests.
Serum IgE may also be used to screen for parasitic infections or aid in diagnosing other illnesses.
This medication can also be used off-label to treat other conditions.
Xolair should not be used for the emergency treatment of any allergic reactions.
It is an important antibody in fighting off parasites.
Extremely high or undetectable levels of IgE are linked to various health problems.
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