MSM (methylsulfonylmethane) is a popular supplement among people with chronic pain.
It’s also believed to protect cartilage.
MSM is also believed to counter oxidative stress and improve antioxidant capacity.

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It’s under investigation as a cancer treatment, as well.
It passes readily through the blood-brain barrier and is distributed throughout the brain.
MSM is a naturally occurring sulfur compound found in many foods.
In its pure form, it’s an odorless, tasteless, white, water-soluble, crystalline solid.
It’s few known side effects are typically mild.
Dietary Sources of MSM
It’s not hard to get MSM via your diet.
As foods are processed, MSM is destroyed.
You may be able to increase the amount you get in food by concentrating on fresh whole foods.
Natural vs. DMSO is available in an industrial grade and a medical-grade.
MSM is also available as atopical cream.
The result of lowered inflammation and cartilage preservation is an improved range of motion and physical function.
This is believed to be due to its antioxidant effects.
However, researchers haven’t yet specifically explored MSM’s relationship with alcohol.
Until more is known, it’s best to be cautious with alcohol while you’re taking MSM.
Before Trying MSM
Be sure to inform your healthcare provider that you are going to take MSM.
Interactions between MSM and other prescription medications, non-prescription medications, dietary supplements, orherbal remediesare possible but unknown.
If you are going to buy MSM, it is important to buy from a reputable manufacturer or vendor.
Choose a product with a USP notation (for US Pharmacopoeia standards).
It is important to select a quality brand.
Different brands may vary in the amount of active ingredient they contain.
After starting MSM, allow a reasonable amount of time to notice any benefits.
Frequently Asked Questions
MSM, methylsulfonylmethane, is a supplement that can ease pain and inflammation.
It is marketed as a treatment for arthritis, osteoarthritis, gout, and exercise-related muscle pain.
It is unclear whether MSM affects gut health.
In addition, taking MSM may cause stomach upset or diarrhea.
MSM crosses the blood-brain barrier, but its effects on the brain are unknown.
Butawan M, Benjamin RL, Bloomer RJ.Methylsulfonylmethane: Applications and safety of a novel dietary supplement.Nutrients.
2017; 9(3):290. doi:10.3390/nu9030290
Arthritis Foundation.Supplement and herb guide for arthritis symptoms.
Butawan M, Benjamin RL, Bloomer RJ.Methylsulfonylmethane: Appplications and safety of a novel dietary supplement.Nutrients.
2017 Mar 16;9(3).