Whether isotretinoin is worth it is a decision that only you and your dermatologist can make together.

This article explains how isotretinoin works and the side effects it can cause.

It also covers the requirements you will need to follow while using isotretinoin to prevent serious side effects.

An Asian girl looks at severe acne on her cheek in a compact mirror.

Boy_Anupong / Getty Images

Boy_Anupong / Getty Images

What Is Accutane (Isotretinoin)?

Isotretinoin is a medication used to treatsevereornodular acnethat doesn’t improve with other treatments.

Accutane was formerly a popular brand name of isotretinoin that’s no longer being sold.

However, some people still refer to isotretinoin as Accutane.

How Does Isotretinoin Work?

Isotretinoin is an oral medication that comes in capsule form.

Isotretinoin is the only medication that effectively targets all four causes of acne.

The medication:

Most people take this drug for four to six months.

Some people need to take it for an additional four to six months to see an improvement.

Isotretinoin may also prevent acne scars.

After using isotretinoin:

The benefits of Isotretinoin go beyond improvements in acne.

How long does it take for isotretinoin to clear acne scars?

Isotretinoin doesn’t have any effect on existing acne scars.

However, some of the red and brown spots on your skin will clear up as your acne heals.

If you or a loved one are in immediate danger, call911.

It’s unknown whether this may harm a fetus, but conception should be avoided.

What Are the Requirements Before Prescribing?

Prescribers, patients, and even pharmacies must be registered with the FDA-approved iPLEDGE program.

Neither is using aninternal condomor therhythm method.

Who Shouldn’t Take Isotretinoin?

You should not take isotretinoin if:

Do not get pregnant while on isotretinoin.

How to Decide if Isotretinoin Is Worth It?

Remember that it can take several weeks for isotretinoin to start showing results.

Summary

Isotretinoin is the strongest and most effective acne medication available.

Most people who use it will experience dry skin and lips.

Although rare, the drug is also linked to depression and suicidal thoughts.

Using isotretinoin when pregnant will result in birth defects.

If you have any questions about isotretinoin, talk to your dermatologist.

American Osteopathic College of Dermatology.Accutane.

American Academy of Dermatology Association.Isotretinoin: FAQs.

Food and Drug Administration.Isotretinoin capsule information.

doi:10.7759/cureus.16834

National Organization for Rare Disorders.Fetal retinoid syndrome.

U.S. Food and Drug Administration: FDA AccessData.Accutane (isotretinoin capsules).

Gurel A, Gurel G, Frat F.Effect of systemic isotretinoin therapy on semen parameters.Ann Med.

2023 May;55(1):2207038. doi:10.1080/07853890.2023.2207038

National Library of Medicine.

HealthLink BC.Acne: Should I take isotretinoin for severe acne?

University of Michigan.How dermatologists treat acne: 5 options explained.

American Academy of Dermatology Association.Lasers and lights: How well do they treat acne?

Baldwin HE.Pharmacologic treatment options in mild, moderate, and severe acne vulgaris.Semin Cutan Med Surg.

2015;34(5 Suppl):S82-5.

2016;74(5):945-73.e33.