That means it is a substance produced during metabolism.
In other words, consuming S6A is not the same thing as consuming Splenda.
The aforementioned study referenced previous research in which rats were administered sucralose.
Photo Illustration by Michela Buttignol for Verywell Health; Getty Images
Up to 10% of the dose came out as S6A in their fecal samples.
The findings from the rodent model suggests that only 10% of sucralose is metabolized to S6A.
But for two participants, the concentration spiked even more, exceeding 1,500 ng/mL.
An older study from 2000 also looked at blood concentrations after a dose of sucralose.
The peak of 600 g/mL still doesnt reach S6As lowest observed concentration for genotoxicity.
The amount tested in the study is very high and its intake is impossible, Urrialde said.
You would be consuming an excessive amount of sucralose before you reach the DNA damage threshold for S6A.
However, the bacterial reverse mutation tests reveal that sucralose and S6A are both non-mutagenic.
But further research is needed to understand how sucralose and S6A interact with the body.
The study was conductedin vitroand is not comparable toin vivoresearch, Urrialde said.
Human trials are needed, “not just studies in rodents andin vitro.
A study published last year inBMJreported an association between higher artificial sweetener consumption and increased cardiovascular disease risk.
Food and Drug Administration.Aspartame and other sweeteners in food.
2000;38(Suppl 2):S123-S129.
2022;378:e071204.
doi:10.1136/bmj-2022-071204
World Health Organization.WHO advises not to use non-sugar sweeteners for weight control in newly released guideline.
