The observational study included more than 1.5 million people in Israel who mostly received the Pfizer mRNA COVID-19 vaccine.

Those who got the shot between 10 a.m. and 2 p.m. seemed to experience fewer breakthrough infections.

Why Does the Time of Day Matter When We Get a Vaccine?

COVID time of day

Photo Illustration by Zack Angeline for Verywell Health; Getty Images.

Scientists have been studying how circadian rhythms can affect vaccine response.

Or they can be more willing to actually get vaccinated.

Ultimately, its most important to get vaccinated no matter what time works best for you.

For the most recent updates on COVID-19, visit ourcoronavirus news page.

2021;19(1):37. doi:10.1186/s12964-021-00721-2

National Institute of Allergy and Infectious Disease.Vaccine adjuvants.

2022;10(10):1747. doi:10.3390/vaccines10101747