They boost sexual performance in males by improving blood flow to the penis but do not affectlibido.
Addyi and Vyleesi work differently.
To reflect our sources accurately, this article uses terms as the sources use them.

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Neither medication is approved for use in males and neither has any effect on physical sexual performance.
Addyi
Addyi is a serotonin 5-HT-receptor agonist.
It affectsserotoninand other natural substances in the brain, but the exact mechanism of action is unknown.
Instead, a level is established in your body.
It can take several weeks to start working.
You should stop taking it if there’s no improvement after eight weeks.
Vyleesi
Vyleesi is a melanocortin receptor agonist.
People withliver diseaseshould not take Addyi.
They may develop localized areas ofhyperpigmentation(areas of darkened skin).
People with uncontrolled high blood pressure should not take Vyleesi.
Do not take Addyi if you also take moderate or strong CYP3A4 inhibitors.
Vyleesi can slow absorption and make some oral medications, such as antibiotics, less effective.
Do not use it if you take oral naltrexone products for alcohol or opioid addiction.
Check with a healthcare provider or pharmacist before trying products that claim to boost libido.
The FDA cautions that some of these products may contain hidden ingredients that harm your health.
Your provider will want to rule out health conditions, medications, and other problems contributing to low libido.
Even with a diagnosis, there’s still a lot to consider.
The two drugs have different routes of administration.
Underlying causes of low sexual desire include:
Treatment depends on the specific cause.
Finding ways to manage stress and treating chronic medical conditions may help improve sexual desire.
Viagra doesn’t affect libido and isn’t approved for use in females.
With a diagnosis of FSIAD/HSDD, these “female Viagra” drugs may be an option.
Your provider can explain the benefits and risks based on your situation and personal preferences.
Barakeh D, Mdaihly H, Karaoui LR.Pharmacotherapy of Hypoactive Sexual Desire Disorder in Premenopausal Women.Ann Pharmacother.
2025 Feb;59(2):148-161. doi:10.1177/10600280241253273
DailyMed.Label: Viagra- sildenafil citrate tablet, film coated.
DailyMed.Label: Addyi- flibanserin tablet, film coated.
DailyMed.Label: Vyleesi- bremelanotide injection.
How A, Jowdy C, Novatcheva E, Clayton AH.Novel Pharmacologic Treatments of Female Sexual Dysfunction.Clin Obstet Gynecol.
2018 Jan;15(1):43-51. doi:10.1016/j.jsxm.2017.11.005
U.S. Food & Drug Administration.Drug trials snapshots: Addyi.
Vyleesi- bremelanotide injection.Package insert.
2023 Nov 30;15(11):e49690.
doi:10.7759/cureus.49690
Dording CM, Sangermano L.Female sexual dysfunction: natural and complementary treatments.FOC.
2018;16(1):19-23. doi:10.1176/appi.focus.20170049
Finley N.Lifestyle choices can augment female sexual well-being.Am J Lifestyle Med.
2017;12(1):38-41. doi:10.1177/1559827617740823