What Is Letrozole?
Letrozole is an aromatase inhibitor that prevents the conversion of androgen to estrogen.
It is commonly used to treat estrogen-dependent tumors, particularly breast cancer, in peri-menopausal or post-menopausal women.

Buena Vista Images / Getty Images
This is a common cause of infertility in PCOS, described as anovulatory infertility.
Over the past years, it has emerged as the first-line treatment for anovulatory infertility in PCOS.
It works by improving endometrial thickness and encouraging healthy ovarian follicular development.
You may need monitoring through blood tests and/or ultrasounds to determine when you are approaching ovulation.
Letrozole should be stopped as soon as pregnancy is achieved.
This medication is incompatible with pregnancy and breastfeeding.
Side Effects
Overall, letrozole is well tolerated.
Side effects may include:
Kar S.Current evidence supporting “letrozole” for ovulation induction.J Hum Reprod Sci.
Int J Fertil Steril.
2015 Apr-Jun; 9(1): 1726.