Important Information

Methotrexate prescribing information comes with what’s called aboxed warning.

This is the strongest warning a medication can have and still be prescribed in the U.S.

The boxed warning for methotrexate is quite long and can be a little scary.

Methotrexate pills on a gray background

Pillbox / National Library of Medicine

If you notice any other effects, check with your healthcare provider.

PDR.Methotrexate: boxed warning.

PDR.Methotrexate: adverse reactions.

Food and Drug Administration.Methotrexate injection, USP.

Food and Drug Administration.Methotrexate tablets, USP.