Nicotinamide riboside (NR) is a popular anti-aging nutrient but it has many possible benefits.
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Importance of Supporting NAD+
Nicotinamide riboside is a form of vitamin B3.
Ensuring your body has a constant supply of NAD+ is crucial.
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Every cell in your body needs NAD+ to produce energy.
Additionally, two groups of enzymes depend on NAD+ for their synthesis.
NAD+ naturally decreases with age.
you’re able to’t maintain healthy NAD+ levels if you dont get enough vitamin B3.
Anti-Aging Benefits
NR supplements may slow the aging process through the influence of NAD+ on SIRTs.
While all three activities fight aging, DNA repair is the key to longevity.
Every time your DNA replicates, it sustains a little wear-and-tear damage.
Sirtuins are needed to repair DNA, maintaining genetic stability, and slowing the DNA damage responsible for aging.
This showed NR’s potential neuroprotective effects (protecting the nerves and brain).
This review found the most substantial evidence for the potential usefulness of NAD+ in Alzheimer’s disease and dementia.
No supplement is intended to treat, cure, or prevent disease.
NAD+ fuels your metabolism, giving it a potential role in weight loss.
A review of studies published in 2023 explored the role of NAD+ in more than 5,000 people.
Lower Cancer Risk
Free radicals are a natural byproduct of metabolism.
These changes lead to DNA changes that develop into cancer.
NAD+ is a potent antioxidant that may stop free radicals.
It can also lower your risk for cancer through its ability to repair DNA damage and reduce inflammation.
Treat Jet Lag
NAD+ regulates the body’s sleep-wake cycle (circadian rhythms).
Dosage
NR supplements are generally considered to be safe.
The European Commission identified a UL of 900 mg per day.
The FDA gave one NR supplement, Niagen, GRAS (generally recognized as safe) status.
However, you should consult your healthcare provider before taking NR supplements along with other supplements containing NAD+ precursors.
As a result, some supplement products may not contain the ingredients listed on the label.
NAD+ is essential for your health as its used to produce energy and supports numerous body processes.
Through NAD+, NR may slow aging, improve cardiovascular health, and provide other health benefits.
There are no known side effects other than flushing if you take more than the recommended daily dose.
Sharma C, Donu D, Cen Y.Emerging role of nicotinamide riboside in health and diseases.Nutrients.
2022;14(19):3889. doi:10.3390/nu14193889
Oregon State University: Linus Pauling Institute Micronutrient Information Center.Niacin.
Podyacheva E, Toropova Y.Nicotinamide riboside for the prevention and treatment of doxorubicin cardiomyopathy.
2019;9(1).
doi:10.1038/s41598-019-46120-z
Food and Drug Administration.GRAS Notice (GRN) No.
Conlon N, Ford D.A systems-approach to NAD+ restoration.Biochemical Pharmacology.
2022 Oct 1;21(10):1129-1132. doi:10.36849/JDD.6870.
2022;22(1).
2022;34(3).
doi:10.1016/j.cmet.2022.02.001
Campbell JM.Supplementation with NAD+ and its precursors to prevent cognitive decline across disease contexts.Nutrients.
2019;28(7).
2018;9(1).
2023 Aug 15;28(16):6078. doi:10.3390/molecules28166078.
2023 Oct 3;10:1208734. doi:10.3389/fnut.2023.1208734.
Nakahata Y, Bessho Y.The Circadian NAD+Metabolism: Impact on Chromatin Remodeling and Aging.Biomed Res Int.
2016;2016:3208429. doi:10.1155/2016/3208429.
Braidy N, Liu Y.NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis.Experimental Gerontology.
