Ulcerative colitis is a difficult disease to treat.
Ulcerative colitis is a condition that causes bloody stool, abdominal pain, and frequent urges to poop.
Velsipity is the second S1P modulator to gain FDA approval for treating ulcerative colitis.

Illustration by Julie Bang for Verywell Health
Two-thirds of the participants had never taken a biologic or JAK inhibitor drug.
Another three-month clinical trial yielded similar results to the first trial.
Because Velsipity is an anti-inflammatory medication, it can also hinder the immune system.
Pfizer said patients may be more susceptible to infections in the five weeks after starting Velsipity.
There wasnt a massive difference in outcomes between the treatment and placebo groups.
The important thing is to figure out for which patients this is the right therapy.
Providers often combine multiple therapies to best address a patients individual needs.
People living with the disease can cycle through several different treatments over time.
There are non-medication treatments and practices that can help quell ulcerative colitis.
Some people who dont respond to medications may choose to undergo surgery to remove the colon.
Lifestyle modifications can also help.
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