Primatene Mist inhalers (epinephrine inhalation aerosol) provide temporary relief from mild, intermittent asthma symptoms.
Why Was Primatene Mist Taken off the Market?
After reformulating with HFA propellant and changing the inhaler gadget, Primatene Mist became available OTC again in 2018.

RgStudio / Getty Images
Primatene Mist vs. Albuterol
Primatene Mist and albuterol are different medications.
They have different active ingredients, uses, and side effects:
Is Primatene Mist Safe?
Researchers have studied whether or not this practice is safe.
In general, Primatene Mist appears safe if used appropriately.
What Is Primatene Mist Used For?
You shouldn’t use an OTC asthma medication to avoid seeking medical care for asthma.
If you’re considering using Primatene Mist, consult a healthcare provider first.
Asthma is a serious condition that can get worse quickly.
Serious Side Effects
Some Primatene Mist side effects require immediate medical attention.
However, also like Primatene, Asthmanefrin was significantly less effective at controlling asthma symptoms than prescription albuterol.
The programs are all very different and will have different rules and qualification standards.
Summary
Primatene Mist inhalers provide temporary relief from mild, intermittent asthma symptoms.
Primatene and prescription albuterol are different medications, with different active ingredients, uses, and side effects.
Nervousness, tremors, and increased heart rate are among the common side effects of Primatene Mist.
Serious side effects include worsening asthma symptoms and allergic reactions.
When buying online, use a reputable supplier with standard pharmacy credentials and staff.
Free or low-cost asthma medications are available through assistance programs.
Primatene.com.News & Views - FDA Approves Primatene MIST.
Sadreameli SC, Brigham EP, Patel A.The surprising reintroduction of primatene mist in the United States.Annals ATS.
DailyMed.PRIMATENE MIST- epinephrine inhalation aerosol.
DailyMed.ALBUTEROL SULFATE HFA- albuterol sulfate aerosol, metered.
Food & Drug Administration.
Center for Drug Evaluation and Research.Summary review for regulatory action.
Food & Drug Administration.Primatene.
University of Florida, College of Pharmacy.Over-the-counter medicine not the best option for asthma.
Food & Drug Administration.Buying prescription medicine online: a consumer safety guide.
Epinephrine CFC Metered-dose Inhalers - Questions and Answers