Prozac contains the active ingredientfluoxetine, while Lexapro contains the active ingredientescitalopram.

In addition to treating depression, both drugs can treat other mood disorders, includinganxiety.

This article will compare Prozac and Lexapro, including their uses and side effects.

Prozac vs. Lexapro (Drug Article)

Evgeniia Siiankovskaia / Getty Images

While Prozac and Lexapro are both SSRIs, they have significant differences.

Which Drug Lasts Longer?

Prozac is eliminated from the body slower than all other SSRIs, including Lexapro.

The longer the half-life, the longer the duration of action.

Which Is More Effective?

They are also better tolerated than other types of antidepressants.

With that said, there is no evidence that one antidepressant is inherently superior to another, including SSRIs.

Arguably, the only differentiating factor is the discontinuation of treatment due to drug intolerability.

How Do SSRIs Work?

By doing so, more serotonin is available in circulation to act on brain receptors.

Who Shouldn’t Use Prozac or Lexapro?

Prozac or Lexapro have similar contraindications (meaning conditions in which the drugs should never be used).

Seek immediate medical treatment if you experience signs or symptoms of any of these medical conditions.

People in these age groups should be closely monitored for any changes in behavior or mood while on treatment.

Some of these interactions can be significant.

leading to increased side effects or reduced drug efficacy.

Prozac is approved to treat major depressive disorder (MDD), obsessive-compulsive disorder (OCD).

bulimia nervosa, and panic disorder.

Lexapro is approved to treat MDD and generalized anxiety disorder (GAD).

Prozac can be used in adults and children 7 years and over.

Lexapro can be used in adults and children 12 and older.

2023;11(5):740. doi:10.3390/healthcare11050740

DailyMed.Prozac - fluoxetine hydrochloride capsule.

DailyMed.Lexapro - escitalopram tablet, film coated.

Lexapro - escitalopram solution.

National Alliance on Mental Illness.Fluoxetine (Prozac).

National Alliance on Mental Illness.Escitalopram (Lexapro).

2023;107(2):123-124.

Kendrick T, Taylor D, Johnson CF.Which first-line antidepressant?Br J Gen Pract.

doi:10.1016/S2215-0366(24)00133-0

MedlinePlus.Antidepressants.

Jones LA, Sun EW, Martin AM, Keating DJ.The ever-changing roles of serotonin.Int J Biochem Cell Biol.