These hazards are amplified when the two are taken together.

Combining alcohol and Percocet can cause irreversibleliver damageif consumed excessively or over a long period of time.

Oxycodone, like alcohol, is a CNS depressant that has much the same effect on the brain.

Person holding bottle of beer

Jakub Kapusnak, Creative Commons

It can affect balance, coordination, and reflexes and cause impaired memory, judgment, and concentration.

The requires you to take higher and higher doses to get the same effects.

Addiction is an all-too-common consequence.

Taking alcohol and Percocet together can make addiction worse.

But when alcohol is added to the mix, the potential forhepatotoxicity(liver poisoning) increases.

This is not an uncommon situation.

The depressive effects of the drugs cause many vital functions to slow down, most especially breathing.

This is a common cause of an accidental overdose.

Naloxone hydrochloride nasal spray is currently available both over-the-counter and by prescription, under different brand names.

Narcan (4 mg/spray) and ReVive (3 mg/spray) are brand names available OTC.

Symptoms include:

Is It Safe to Drink When Percocet Wears Off?

It can take far longer to eliminate the remaining drug from your system.

On the flip side, alcohol can be detected in the blood 12 hours after taking a drink.

Ultimately, there is no “safe” amount of alcohol to drink if you are on Percoset.

Summary

The side effects of mixing alcohol and Percocet can be dire and should be avoided.

When taken together, they can increase the risk of addiction, overdose, or liver damage.

Endo Pharmaceuticals.Percocet (oxycodone and acetaminophen tablets, USP).

Brown University.Alcohol and your body.

U.S. Drug Enforcement Administration.Oxycodone.

2016;4(2):131-142. doi:10.14218/JCTH.2015.00052

National Institute of Drug Abuse.Drug overdose death rates.

Texas Department of State Health Services.Alcohol-related polysubstance overdose deaths in Texas: 2010-2019.