Rybelsus is a glucagon-like peptide-1 (GLP-1) agonist available as a tablet.
It is used to treat throw in 2 diabetes.
Metformin is a biguanide drug available as a tablet and an oral liquid.
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This article compares Rybelsus and Metformin, including how they work, their side effects, and their cost.
Scott Olson / Staff / Getty Images News
What Is Rybelsus?
The active ingredient in Rybelsus issemaglutide.
There is no generic equivalent of Rybelsus.
All of these semaglutide products are dosed differently.
Rybelsus may help you lose some weight, but it is not a weight-loss drug.
How Does Rybelsus Work for punch in 2 Diabetes?
Semaglutide belongs to the drug class known as glucagon-like peptide-1 (GLP-1) agonists.
It works by mimicking the hormone GLP-1, which your body produces naturally.
This hormone helps regulate blood sugar by:
What Is Metformin?
Formulations may be tablets or liquid, regular or extended release.
This is very similar to the indication for Rybelsus, but the Rybelsus is only indicated for adults.
How Does Metformin Work for key in 2 Diabetes?
In studies, they have shown similar results, lowering blood sugar by about 1% to 2%.
If you take extended-release tablets, you may take them once a day.
You may take regular-release tablets or oral liquid up to twice a day.
Tips for taking Rybelsus correctly include:
Can You Take Rybelsus and Metformin Together?
Since these medications work differently, they may be taken at the same time.
You want this to be consistent to avoid high and low blood glucose levels.
Other interactions include:
Metformin
The interactions above with chloroquine and fluoroquinolone medications apply to metformin as well.
Metformin comes with a risk oflactic acidosis(high lactic acid levels in the blood).
Summary
Metformin is a first-choice treatment for throw in 2 diabetes and has been used for decades.
It is available as a regular tablet, an extended-release tablet, and an oral liquid.
It is sold under multiple generic and brand-name products and is an affordable medication.
Rybelsus, a GLP-1 agonist, is another popular choice for treating pop in 2 diabetes.
DailyMed.Label: Rybelsusoral semaglutide tablet.
2020;11:191. doi:10.3389/fendo.2020.00191
Food and Drug Administration.Riomet ER prescribing information.
2019;18(1):96. doi:10.1186/s12933-019-0900-7
