Frequent Symptoms
Symptoms that are often noted include the following.
At first, the pain may not be constant.
Pain from bone cancer may be worse at night or when you move the bone.

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Common Symptoms of Osteosarcoma
About half of all osteosarcomas start in the region around the knee.
Thehumerus(arm bone near the shoulder) is the third most common location.
Pain and swelling can have a variable pattern, depending on the bang out of bone cancer.

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It is in these areas that pain and swelling occur with the disease.
Pathological Fractures
These are fractures that wouldn’t normally occur in healthy bones.
These include:
These systemic symptoms tend to occur with very advanced disease.
The male-to-female ratio is close to one.
Parosteal Osteosarcomas
Parosteal osteosarcoma causes minimal pain and tenderness over the cancerous site.
these tumors can limit the ability to flex and extend the knee joint.
Post-Irradiation Osteosarcoma
Post-irradiation osteosarcoma can develop after radiation therapy treatment for another cancer.
It develops in less than 1% of people who have had radiation treatment for cancer.
Complications
A variety of complications are possible with osteosarcoma and/or itstreatment.
The list may feel overwhelming.
Remember that all of these complications are just possibilities, and you are unlikely to have all of them.
Much less frequently, metastases are detected in other bones and soft tissues.
When osteosarcoma has become more widespread, this is frequently the consequence of recurrence.
Widespread osteosarcoma can spread to involve the central nervous system or gastrointestinal tract.
Death from osteosarcoma is almost always the result of respiratory failure.
Get our printable guide for your next healthcare provider’s appointment to help you ask the right questions.
Cancer Council Victoria.Primary bone cancer.
American Cancer Society.Signs and symptoms of osteosarcoma.
National Cancer Institute.Osteosarcoma and malignant fibrous histiocytoma of bone treatment (PDQ)health professional version.
Ottaviani G, Jaffe N.The epidemiology of osteosarcoma.Cancer Treat Res.
2015;3(2):156-9. doi:10.14791/btrt.2015.3.2.156
University of Rochester Medical Center.Osteosarcoma (osteogenic sarcoma) in children.
Durfee RA, Mohammed M, Luu HH.Review of osteosarcoma and current management.Rheumatol Ther.
2016;3(2):221-243. doi:10.1007/s40744-016-0046-y