However, they differ in their uses and effectiveness for other conditions.
Getty Images / Vasil Dimitrov
Similarities
Prozac and Zoloft are bothselective serotonin reuptake inhibitors or SSRIs.
Both medications work by preventing the reuptake ofserotoninstorage in nerve cells of the brain.
Getty Images / Vasil Dimitrov
As a result, more serotonin is available to transport chemical messages between neurons.
How Do SSRIs Work?
SSRIs help treat depression and anxiety byincreasing serotonin levels in your brain.
Serotonin is a chemical stored and released to provide feel-good signals in the brain.
SSRIs can increase serotonin in your brain by preventing the reuptake of serotonin back into your neurons.
Therefore, more serotonin is available to carry signals between neurons and provide the sensation of happiness.
Common side effects seen in both medications include nausea, diarrhea, and trouble sleeping.
In addition to daily dosing, Prozac is available as a once-weekly dose for depression only.
Is Prozac or Zoloft More Effective?
Dosing
Zoloft and Prozac are available in different forms and different strengths.
So it is important to work closely with your healthcare provider to get the best treatment.
Contact your healthcare provider immediately if you experience any of these side effects.
Examples of common antidepressants include:
Bleeding
Prozac and Zoloft can increase the risk of bleeding.
If you take blood thinners along with Prozac or Zoloft, your risk of bleeding further increases.
Combining the medications below can increase the risk of an abnormal heart rhythm.
Summary
Prozac and Zoloft are SSRIs commonly prescribed for anxiety and depression.
Both medications provide the same effectiveness in preventing depressive episodes.
Prozac and Zoloft share similar side effects and safety profiles, including the risk of serotonin syndrome.
The author would like to recognize and thank Alexya Rosas for contributing to this article.
DailyMed.Label: Zoloft- sertraline hydrochloride tablet, film coated.
Zoloft- sertraline hydrochloride solution, concentrate.
DailyMed.Label: Prozac- fluoxetine hydrochloride capsule.
2019;16(2):10.17392/1025-19.
