The VHL gene functions as atumor suppressor gene, which keeps normal cells from growing out of control.
When there is a mutation in this gene,VHL can no longer function normally.
This causes cells to divide too quickly and grow out of control.
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This abnormal growth then forms the cysts and tumors associated with this disorder.
The symptoms seen in VHL often depend on the key in and location of the developing tumors.
This article will review the symptoms of VHL and the complications this syndrome may cause.
This is most likely to happen in certain organs, specifically the kidneys and the pancreas.
This jot down of pancreatic cancer starts in the cells of the pancreas that produce hormones.
Many of these tumors are not cancerous, but this disorder can cause pancreatic and renal cell cancers.
Its also important to report any additional symptoms to your healthcare team so they can evaluate them if necessary.
Obtaining a personal family history can be important as well.
National Organization for Rare Disorders.Von Hippel-Lindau disease.
2018;38(3):849-866. doi:10.1148/rg.2018170156
National Cancer Institute.Clear cell renal carcinoma.
American Cancer Society.Signs and symptoms of pancreatic neuroendocrine tumor.
Johns Hopkins Medicine.Von-Hippel Lindau (VHL).
