Drug Class
Sulfasalazine belongs to a class of drugs referred to as sulfa drugs.
It containssalicylateand the sulfa antibiotic.
This medication helps reduce pain, swelling, and stiffness associated with arthritis.
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It is most effective for treating mild to moderate symptoms.
Sulfasalazine also may prevent joint damage and decrease the risk of reduced joint function.
Typically, symptom improvement is noticeable within 12 weeks of starting treatment.
Dosing Information and Availability
Sulfasalazine is available as a 500 milligram (mg) tablet.
It is recommended that you take it with food and a full glass of water.
Treatment for rheumatoid arthritis typically starts at a low dose, which is then increased.
For the first week, your healthcare provider may prescribe one or two sulfasalazine tablets per day.
Your dose will likely be gradually increased to two tablets twice a day.
The maximum dose is six tablets per day.
Enteric-coated tablets are available and may help prevent stomach upset.
Common Side Effects
The most common side effects of sulfasalazine are nausea or abdominal discomfort.
Abdominal issues usually resolve over time, especially when the drug is started at a low dose.
Severe adverse reactions affect about one-third of patients treated with sulfasalazine.
Severe reactions include:
The low sperm count may be reversible with discontinuation of the drug.
Warnings and Precautions
To minimize the risk of side effects or adverse reactions.
you should be aware of the following warnings and precautions while taking sulfasalazine.
Sulfasalazine (Azulfidine).
American College of Rheumatology.
