Some drugs strongly inhibit the CYP2D6 enzyme, which prevents adequate production of endoxifen from tamoxifen.
This would substantially reduce the effects of the drug for you.
Most doctors recommend that you avoid taking strong and moderate inhibitors of CYP2D6 while you’re on tamoxifen.
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Medications
Antidepressantsare among the medications that can interact with tamoxifen.
There are no large studies looking at the interaction of herbal supplements with tamoxifen.
One recent study found no interaction between green tea supplements and tamoxifen.
If you plan on using any herbal supplements, it’s important to talk to your oncologist.
It can interact with many medications, including those used for depression, diabetes, and heart disease.
It can also interact with some supplements, such as high-dose vitamin E supplements.
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