For this reason, many of the drugs may have fewer side effects than chemotherapy.
The presence of HER2 receptors may result in the growth and proliferation of HER2-positive cancers.
They come in pill form and includeLynparza (olaparib)andTalzenna (talazoparib).
Verywell / Gary Ferster
Poly ADP ribose polymerase (PARP) proteins normally help repair damaged DNA inside cells.
PARP inhibitors work by blocking the PARP proteins.
Olaparib can be used in women who have already received hormone therapy if the cancer is hormone receptor-positive.
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It binds to the antigen Trop-2 and inhibits DNA replication and stimulates cell death.
In some cases, the targeted therapyAvastin (bevacizumab)may be considered.
It is classified as an angiogenesis inhibitor.
Angiogenesis inhibitors work by preventing cancers from growing new blood vessels, essentially starving cancer.
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U.S. Food and Drug Administration.FDA approves fam-trastuzumab deruxtecan-nxki for unresectable or metastatic HR-positive, HER2-low or HER2-ultralow breast cancer.
2019;8:29. doi:10.1186/s40164-019-0154-9
DeVita, Vincent., et al.Cancer: Principles & Practice of Oncology.
Cancer of the Breast.
Wolters Kluwer, 2016.
