This article discusses ankylosing spondylitis and how it affects the body’s different systems.

As theinflammationin the spine worsens, the spine tends to curve forward.

The earliest symptoms usually start in the low back at thesacroiliac (SI) joints.

A woman holding her wrist at work

Peter Dazeley/ Getty Images

People with AS have axial disease, which includes spine, shoulders, and hips.

Nervous System

AS can causenervous systemproblems.

This leads to changes in urinary and bowel control.

It may also lead to sexual dysfunction as well.

This can lead to eye and vision problems likeglaucoma.

Cataracts cause the lens of the eye to become cloudy.

People with an inflammatory condition are at an increased risk of cataracts.Uveitisandiritisare common ocular manifestations of AS.

Respiratory System

While it is not common, some people with AS may notice trouble breathing.

This can occur as the spine curves forward, putting pressure on the lungs.

People with AS may also experience stiffening of the chest wall, which makes taking a deep breath difficult.

Circulatory System

People with AS are at an increased risk ofheart disease.

Most inflammatory diseases like AS raise the risk of heart disease from the inflammation that develops.

In addition, people with AS often have trouble sticking with an exercise plan due to pain and stiffness.

Physical activity has been proven to lower the risk of heart disease.

Rashes are common in people with ankylosing spondylitis.

One of the most common skin problems in people with AS ispsoriasis.Psoriatic arthritisand AS are forms of inflammatory arthritis.

The patches are often itchy and painful.

It also found that chronic pain can lead to severe psychological distress, leading todepressionandanxiety.

The more severe your disease is, the more your mental health is affected.

Summary

Ankylosing spondylitis is arthritis that causes inflammation in the joints and ligaments in the spine.

In addition to pain, AS can cause symptoms in several other body systems.

The most common symptoms of ankylosing spondylitis are pain and stiffness.

If you notice other body changes, talk with your healthcare provider.

From there, pain and stiffness can travel up the spine and to other body areas.

The exact cause of ankylosing spondylitis in individuals is unknown.

Researchers believe that genetics and environmental factors can raise the risk of the disease.

Research has shown that mutations in the gene HLA-B27 are associated with ankylosing spondylitis.

Ankylosing spondylitis is a complicated condition that requires a thorough workup with your healthcare team.

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