These insights set the stage for developing new approaches to counteract the effects of this pathway.
What Is Niacin and Why Do You Need It?
When you dont get enough niacin in your diet, it can lead topellagra, said Daibes.
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The condition can cause mental confusion, weakness, diarrhea, loss of appetite, and other serious symptoms.
Niacin was also one of the firstcholesterol medicationsout there, according to Daibes.
Why Is Too Much Niacin Hard on Your Heart?
When niacin breaks down, it produces byproducts known as 2PY and 4PY.
Are There Other Vitamins That Can Become Dangerous When Broken Down?
What Foods and Products Contain Niacin?
It is also added to enriched and fortified foods, such as breads, cereals, and infant formulas.
How Much Niacin Is Dangerous?
Anything beyond that amount poses a risk for toxicity.
The risk is more from supplements, especially if large amounts are taken over time.
Thats why you should always talk to your healthcare provider before starting any kind of vitamin.
National Institutes of Health Office of Dietary Supplements.Niacin: fact sheet for health professionals.
2024;30(2):424-434. doi:10.1038/s41591-023-02793-8
Mount Sinai.Vitamin B3 (niacin).
Cleveland Clinic.Cleveland Clinic-led study discovers link between high levels of niacin a common B Vitamin and heart disease.
National Library of Medicine: MedlinePlus.Pellagra.
National Library of Medicine: MedlinePlus.Niacin for cholesterol.
Chan School of Public Health.Niacin vitamin B3.
