Pleurisyalso called pleuritisrefers to inflammation of the pleura, the membrane that covers your lungs and chest cavity.
The main symptom of pleurisy is sharp chest pain that worsens with deep breathing or when coughing.
This thin layer of fluid reduces friction on the lungs when you breathe in and out.

Verywell / Brianna Gilmartin
The parietal pleura (not the visceral) is innervated by nerves.
That’s why pain arises when it becomes irritated and inflamed.
The chest pain may be felt in the shoulder or neck (referred pain).
In addition, breathing difficulties may arise.
Some are very serious, so immediate medical attention is warranted for pleuritic (or any) chest pain.
This can include an injury to the chest, chest or heart surgery, or lung or pleural cancer.
Answers to these questions can help pinpoint the cause behind your pleurisy.
These findings can provide clues into your underlying diagnosis.
Imaging Tests
The majority of people with pleuritic chest pain will undergo an imaging test.
Thoracentesis
If excess fluid is found in the pleural cavity, a thoracentesis may be done.
In this procedure, a fine needle is inserted through the chest into the pleural space to withdraw fluid.
Biopsy
Less commonly, a pleural biopsywhere a small sample of the inflamed pleura is removedis performed.
This is done to confirm certain diagnoses liketuberculosisor pleural cancer.
Once pain is under control, a healthcare provider will address the underlying etiology.
Drainage of infected fluid through athoracentesismay also be performed.
While being evaluated for pleurisy, attempt to remain calm and patient.
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