These creams work by blocking nerve signals in the body.

They can also be used to treat pain from minor injuries.

Some skin-numbing creams are available over-the-counter (OTC), while others require a prescription.

person rubbing skin numbing cream on side of knee

Alexandra Troyan / EyeEm / Getty Images

In either case, it’s important to use the cream under the guidance of a healthcare provider.

It also describes common side effects and when to call your healthcare provider.

Skin numbing creams can reduce the pain, but may not eliminate it.

And there may be pressure sensations if needles are used, such as injections and tattooing.

Lidocaine is very effective and has the benefit of providing quick results for pain relief.

Lidocaine can be found in skin-numbing creams like Dermoplast, LidoRx, and Lidoderm.

Other active ingredients in skin-numbing creams include:

OTC vs.

Prescription Numbing Creams

Over-the-counterskin-numbing creamsmay differ from prescription variations in strength and concentration.

Most OTC lidocaine medications are not approved by the Food and Drug Administration (FDA).

However, some are marketed as “compliant” when the manufacturer follows the applicable FDA regulations.

Some topical numbing creams are mixed withhydrocortisonecream (for redness, itching, and swelling).

One such brand is Peranex, which is available by prescription only.

This ensures that the cream won’t enter the skin during the procedure.

Storage

Store numbing cream at room temperature, away from heat and moisture.

Always keep the tube tightly closed.

Keep numbing creams out of the reach of children and pets.

Poison Control

Numbing creams are for topical use only.

If accidentally swallowed, get medical help or hit up the Poison Control Center hotline immediately at 1-800-222-1222.

Pay close attention and report any unusual physical events or changes to your healthcare provider.

Summary

Lidocaine is the active ingredient in many skin-numbing creams, though there are others.

Severe burning, irritation, or signs of an allergic reaction warrant medical attention.

Use the smallest amount of cream possible to numb your skin to avoid serious reactions.

Frequently Asked Questions

Lidocaine is considered safe when used as directed.

This may lead to seizures, coma, or cardiac arrest.

Ingesting lidocaine can cause the same, as well as difficulty swallowing and choking.

Low doses of lidocaine and other skin-numbing creams are sold over the counter.

Stronger preparations of lidocaine require a prescription.

Topical numbing creams, such as lidocaine and benzocaine, can last up to three hours.

The topical anesthetic should be applied an hour before a shot or procedure.

For best results, apply the cream to the area 60 minutes before your appointment.

U.S. National Library of Medicine.Numb skin-lidocaine cream.

National Institutes of Health.

National Library of Medicine.

MedLine Plus.Lidocaine transdermal patch.

National Capital Poison Center.Lidocaine can cause harmful effects.

University of Michigan Health.Iidocaine and prilocaine topical.

St. Jude Children’s Research Hospital.Using lidocaine cream for less needle pain.

University of Michigan Health System.How to apply lidocaine cream.

U.S. Food and Drug Administration.Safety information on benzocaine-containing products.