Over time, this inflammation can lead to scarring, liver failure, or even cancer.
Nearly 15 million people in the United States have MASH, but the condition is likely underdiagnosed.
Until then, physicians primarily relied on lifestyle changessuch as weight loss and regular exerciseto manage the condition.
Photo Illustration by Amelia Manley for Verywell Health; Getty Images
While Rezdiffra marks an important advancement in MASH treatment, its not effective for everyone, Shetty said.
Rezdiffra is effective in about a third of patients, Shetty said.
So there is certainly a need for more effective treatments.
This makes them more enthusiastic about continuing drug development in this area.
And there are many promising medications coming along.
Emerging research also shows that GLP-1 drugs may help stop liver disease from progressing into MASH.
But once someone has MASH, these drugs have not yet been proven to reverse it, Mehal said.
However, he added that early data from clinical trials are showing promising results.
Lifestyle changes like improving diet and increasing physical activity are essential to managing liver disease.
2025;8(1):e2454707.
2024;390(6):497-509. doi:10.1056/NEJMoa2309000
