However, a head-to-head trial is required to directly compare the effectiveness of the two drugs.

This isnt the first head-to-head trial comparing the two drugs.

It would be interesting to see the report on side effects.

An Eli Lilly & Co. Zepbound injection pen

Bloomberg / Contributor/Getty Images

While semaglutide works by activating GLP-1 receptors, tirzepatide mimics both GLP-1 and a second hormone called GIP.

Hurtado Andrade said anticipated weight loss is just one factor to consider when choosing a GLP-1 medication.

However, if someone has pre-established cardiovascular disease, semaglutide may be a better option, she said.

Shared decision-making is the most important aspect of weight management to increase the long-term chances of success.

Cost and accessibility can also factor into the decision-making process.

Talk to a trusted health provider about how to create a medical plan that best suits your health needs.

2022;39(6):2452-2467. doi:10.1007/s12325-022-02153-x